Explores different applications of Aristotle's hypothesis on the components of form, matter and pyschological states.

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

We report on the small-scale (0.5 13 h - 1M, a large-scale bias of ~2.0 and a satellite fraction of 12 ± 2 per cent. Thus, these galaxies occupy haloes with average masses in between those of the higher redshift BOSS CMASS sample and the original SDSS I/II luminous red galaxy sample © 2012 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society © doi:10.1093/mnras/sts314.

This open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 years ago, the Biopsychosocial Model is much cited in healthcare settings worldwide, but has been increasingly criticised for being vague, lacking in content, and in need of reworking in the light of recent developments. The book confronts the rapid changes to psychological science, neuroscience, healthcare, and philosophy that have occurred since the (...) model was first proposed and addresses key issues such as the model’s scientific basis, clinical utility, and philosophical coherence. The authors conceptualise biology and the psychosocial as in the same ontological space, interlinked by systems of communication-based regulatory control which constitute a new kind of causation. These are distinguished from physical and chemical laws, most clearly because they can break down, thus providing the basis for difference between health and disease. This work offers an urgent update to the model’s scientific and philosophical foundations, providing a new and coherent account of causal interactions between the biological, the psychological and social. (shrink)

El presente texto se interroga sobre los efectos performativos del himno de Chile en cuanto éste designa al país en la forma de una "copia feliz del Edén". A partir de ahí, se pregunta ¿cómo podría una copia afirmarse en la originalidad de una soberanía? Para solucionar la distancia entre copia y original y, por tanto, dar lugar al funcionamiento de la soberanía, el himno designa a esa copia como "feliz". El término "feliz" se constituye, así, en el operador que (...) vendría tanto a apuntalar a la constitución de una soberanía como a revelar el límite de su imposibilidad. "Feliz" permite disminuir la distancia entre copia y original, pero a la vez, la conserva irremediablemente. Por eso, decir que el país es la copia "feliz" es lo mismo que decir "infeliz" toda vez que ambos términos no hacen más que corroborar la diferencia ontológica entre copia y original. Se argumenta que el término "feliz" constituye un dispositivo teológico político, toda vez que replica la función angélica destinada a la administración de la creación divina. En estos términos se pregunta: ¿no será el proyecto de la República de Chile un proyecto esencialmente administrativo? A esta luz, el texto plantea la contraposición entre himno con el poema: el himno -se plantea- constituye el operador angélico que hace posible la articulación de una soberanía. El poema, en cambio, constituiría el resto irreductible que le resiste. This essay asks on the performative efects of the chilean hymn, because it names the country as a "happy copy of Eden". Since this problem, the essay asks: how could the copy may posits as the originality of the sovereignity? To solve the distance between the copy and the original and make posible the sovereignity´s operation, the hymn names the copy as "happy". The word "happy" supports the constitution of the sovereignity and reveals the limit of its own imposibility. "Happy" reduce the distance between the copy and the original but, at the same time, absolutely preserve it. That´s why, say that the country is the "happy" copy is the same than to say that is a "unhappy" one, because both words shows the ontological difference between the copy and the original. This essay argues that the word "happy" is a political theological device because repeats the angelical task of manage the divine creation. In theses terms we ask: ¿Is the chilean republican proyect an administrative one? In this light, the essay posits an aporia between the hymn and poem: the hymn constitutes the angelical operator that makes sovereignity posible, the poem constitutes a singular rest that resist it. (shrink)

The question "What is mental illness?" raises many issues in many contexts, personal, social, legal, and scientific. This chapter reviews mental health problems as they appear to the person with the problems, and to family and friends-before the person attends the clinic and is given a diagnosis-a time in which whether there really is a problem, as opposed to life's normal troubles and variations, is undecided, as also the nature of the problem, if such it be, and the related matter (...) what kind of expert advice should be sought. Once at the clinic, a diagnosis may be given-using criteria well-worked-out in the diagnostic manuals. The chapter discusses the conceptualizations of mental disorder in the diagnostic manuals, their rationale, and what can and cannot be reasonably expected of them. There are more position statements than definitions, and while they signal many dilemmas, they do not resolve them. Attempts to do so in the surrounding literature on the concept of mental illness are reviewed in the chapter, with conclusions favoring the features emphasized in the diagnostic manuals: distress and impairment. Finally the chapter considers how far the science may help draw boundaries around mental illness. (shrink)

Scholars of classical philosophy have long disputed whether Aristotle was a dialectical thinker. Most agree that Aristotle contrasts dialectical reasoning with demonstrative reasoning, where the former reasons from generally accepted opinions and the latter reasons from the true and primary. Starting with a grasp on truth, demonstration never relinquishes it. Starting with opinion, how could dialectical reasoning ever reach truth, much less the truth about first principles? Is dialectic then an exercise that reiterates the prejudices of one's times and at (...) best allows one to persuade others by appealing to these prejudices, or is it the royal road to first principles and philosophical wisdom? In From Puzzles to Principles? May Sim gathers experts to argue both these positions and offer a variety of interpretive possibilities. The contributors' thoughtful reflections on the nature and limits of dialectic should play a crucial role in Aristotelian scholarship. (shrink)

Standard economic theory does not capture trust among anonymous Internet traders. But when traders are allowed to have social preferences, uncertainty about a seller’s morals opens t he door for trust, reward, exploitation and reputation building. We report experiments suggesting that sellers’ intrinsic motivations to be trustworthy are not sufficient to sustain trade when not complemented by a feedback system. We demonstrate that it is the interaction of social preferences and cleverly designed reputation mechanisms that solves to a large extent (...) the trust problem on Internet market platforms. However, economic theory and social preference models tend to underestimate the difficulties of promoting trust in anonymous online trading communities. (shrink)

This volume of essays explores major connected themes in Aristotle's metaphysics, philosophy of nature, and ethics, especially themes related to essence, definition, teleology, activity, potentiality, and the highest good. The volume is united by the belief that all aspects of Aristotle's work need to be studied together if any one of the areas of thought is to be fully understood. Many of the papers were contributions to a conference at the University of Pittsburgh entitled 'Being, Nature, and Life in Aristotle', (...) to honor Professor Allan Gotthelf's many contributions to the field of ancient philosophy; a few are contributions from those who were invited but could not attend. The contributors, all longstanding friends of Professor Gotthelf, are among the most accomplished scholars in the field of ancient philosophy today. (shrink)

This chapter discusses reasons why we have no prospect of knowing whether or not matter thinks. It focuses on the mechanist hypothesis, its purported explanatory scope, and John Locke's commitment to it. The chapter then demonstrates God's immateriality and its implications for the possibility that God has given perception and thought to some material things. It addresses the notion of divine superaddition elaborated in letters to Stillingfleet and considers how thinking, extension, solidity, and motion are connected in case they do (...) coexist in the same substance. The whole difference between Locke and his opponents on the epistemic possibility of thinking matter comes down to this. He maintains, and they deny, that we know the fixed nature of substances of various kinds, a constituent of a substance that determines the powers it necessarily has and those it necessarily lacks. (shrink)

The effects of mental disorder are apparent and pervasive, in suffering, loss of freedom and life opportunities, negative impacts on education, work satisfaction and productivity, complications in law, institutions of healthcare, and more. With a new edition of the 'bible' of psychiatric diagnosis - the DSM - under developmental, it is timely to take a step back and re-evalutate exactly how we diagnose and define mental disorder. This new book by Derek Bolton tackles the problems involved in the definition (...) and boundaries of mental disorder. It addresses two main questions regarding mental illness. Firstly, what is the basis of the standards or norms by which we judge that a person has a mental disorder - that the person's mind is not working as it should, that their mental functioning is abnormal? Controversies about these questions have been dominated by the contrast between norms that are medical, scientific or natural, on the one hand, and social norms on the other. The norms that define mental disorder seem to belong to psychiatry, to be medical and scientific, but are they really social norms, hijacked and disguised by the medical profession? Secondly, what is the validity of the distinction between mental disorder and order, between abnormal and normal mental functioning? To what extent, notwithstanding appearances, does mental disorder involve meaningful reactions and problem-solving? These responses may be to normal problems of living, or to not so normal problems - to severe psycho-social challenges. Is there after all order in mental disorder? With the closing of asylums and the appearance of care in the community, mental disorder is now in our midst. While attempts have been made to define clearly a concept of mental disorder that is truly medical as opposed to social, there is increasing evidence that such a distinction is unviable - there is no clear line between what is normal in the population and what is abnormal. 'What is Mental Disorder?' reviews these various crucial developments and their profound impact for the concept and its boundaries in a provocative and timely book. (shrink)

There is in the New Essays a prominent line of argument that Leibniz took to have remarkable scope. If it works, it sweeps away most of the mainstays of Locke’s metaphysics: atoms, vacuum, real space and time, absolute rest, inactive faculties, and the tabula rasa. It alone does not suffice to undermine the possibility of thinking matter, but it contributes support to that most important of Leibniz’s claims against Locke. Because it is so central to the project of New Essays, (...) I am going to focus mainly on the argument as it is employed there; doing so illuminates both the work and the argument. But Leibniz used it a number of times in letters and notes from roughly the same time period and it is related to a thesis in the Discourse on Metaphysics and letters to Arnauld. The argument invokes a distinction between abstract or incomplete entities and concrete or complete ones. Its premises are that atoms, vacuum, inactive substances, and other items on Leibniz’s list are homogeneous or uniform; that all things that are uniform or otherwise exactly alike are abstract; and that nothing abstract can be found in nature. (shrink)

This paper is a defense of the “representative theory of perception” in general, and Locke's views about perception in particular. It is intended only as a limited defense, but one against those objections which recently have been taken thoroughly to discredit both the general theory and Locke's particular position. The chief of these objections is that the representative theory leads inevitably to skepticism about the existence of objective material things. George Pitcher finds this objection to the representative theory completely persuasive (...) and so well established that it scarcely requires discussion:It is just here [in the area of justifying perceptual knowledge of the world] that the most serious and notorious deficiencies of sense-datum theories are encountered. If the sense-datum theorist maintains the existence of physical objects, … as ordinarily conceived, then his claim that sense-data are metaphysically distinct from anything in the physical world commits him to a version of representative realism. The enormous epistemological difficulties [due to their skeptical consequences] faced by theories of this kind are well known, and I shall not say anything about them, except that I regard them as insuperable …. (shrink)

Thus the passage is printed in the Teubner edition of Seneca's Dialogues by E. Hermes, who, on the strength of Aen. 8. 702 f. , adds a note on the quotation ‘versus sunt Vergilii a Seneca licenter mutati’. Now the imputation to Seneca of such gross alteration of Virgil can only be supported if we disregard or eject the evidence to the contrary. As only the last five words are actually Virgilian; as Seneca himself says ‘aput vate nostra?’; as out (...) at the beginning of the second line may introduce a second quotation ; and as est, which Gertz secluded, has a part to play if the lines are by different poets, it is safer to take a step backwards and dispose the passage thus. (shrink)

This article examines the different approaches to the relation between law, state and economy in the works of Hans Kelsen, Carl Schmitt and Evgeny Pashukanis. It begins with Kelsen’s depiction of law as a dynamic and ‘self-regulating’ system of norms, founded on his rejection of ‘dualist’ separations of state and law, before turning to Schmitt and Pashukanis’s respective critiques. For all their differences, both agree Kelsen ignores the historical basis of the law – for Schmitt, the sovereign power of ‘the (...) political’, for Pashukanis, the social relations of commodity exchange. The article responds to these criticisms in a most un-Kelsenian manner, drawing upon historical sociological literature on early modern state formation to cast doubt on both Schmitt and Pashukanis’s historical accounts. It argues that the forms of political power and commodity exchange upon which Schmitt and Pashukanis’s theories rely were historically specific possibilities opened up by the same process of generalisation and depersonalisation of power relations that allowed for an autonomous ‘public’ system of legal norms. Thus, rather than the fixed causal ground for the development of modern law, ‘the political’ and exchange between equals exist in a relation of ‘difference-in-unity’ with the law. The article concludes that Kelsen’s notion of the Grundnorm is best explained as an attempt to capture the new possibilities and responsibilities opened up a normative system whose ultimate justification now lies only within itself. (shrink)

Debates about the concept of mental disorder involve social values, the medical model, and the sciences. It is generally agreed that the concept involves values, though how it does this continues to be disputed, and it is also recognized that the label of mental disorder or illness is stigmatizing. Wakefield's proposed definition of mental disorder in terms of harmful dysfunction locates the concept in an evolutionary theoretic framework. However, recent commentaries on Wakefield's analysis have suggested that research programs in evolutionary (...) biology and psychology envisage a broader class of "treatable conditions" that may involve no dysfunction, and hence no disorder in this sense. (shrink)

This article tracks Corporate Social Responsibility (CSR) as an emergent organizational process that places the employee at its center. Predominantly, research on CSR tends to focus on external pressures and outcomes leading to a neglect of CSR as a dynamic and developing process that relies on the involvement of the employee as a major stakeholder in its co-creation and implementation. Utilizing case study data drawn from a study of a large multinational energy company, we explore how management relies on employees' (...) interaction with CSR as the process of initiation → implementation → maturation develops. Employee involvement grows from a minor element in the CSR initiation stage to a vital contributory factor in CSR's success in the later stages of the process. The article offers new insights into a processual and interactional approach to CSR that accounts for the actions of different actors involved at each stage. Most unusually, it also recognizes the dual impact this has on broader issues concerning the management and involvement of employees through CSR actions, and gaining legitimacy in the eyes of not only external stakeholders but internal too. (shrink)

Shepherd propounds a theory of mind with a fair claim to be better than Hume’s at explaining the sources of commonly held human beliefs about causal necessity due largely to her relational theory of sense perception. In comparison with Hume’s account, it incorporates a more sophisticated treatment of mental representation, especially the role of relational structure and logical form. Most important, perhaps, Shepherd’s theory enforces the division, obscured by Hume, between the evidence of necessity and the metaphysical foundation of necessity.

Iris Murdoch was not only one of post-war Britain's most celebrated and prolific novelists - she was also an influential philosopher, whose work was concerned with the question of the good and how we can see our moral worlds more clearly. Murdoch believed that paying attention to art is a way for us to become less self-centred, and this book argues that cinema is the perfect form of art to enable us to do this. Bringing together Murdoch's moral philosophy and (...) contemporary cinema to build a dialogue about vision, ethics and love, author Lucy Bolton encourages us to view cinema as a way of studying other worlds and moral journeys, and to reflect upon their ethical significance in the world of the film and in our daily lives. (shrink)

Although an elusive concept, "camp" can be found in most forms of artistic expression, revealing itself through an aesthetic of deliberate stylization. Fashion is one of the most overt and enduring conduits of the camp aesthetic. As a site for the playful dynamics between high art and popular culture, fashion both embraces and expresses such camp modes of enactment as irony, humor, parody, pastiche, artifice, theatricality, and exaggeration. Drawing from Susan Sontag's seminal essay "Notes on 'camp,'" the book explores how (...) fashion designers have used their metier as a vehicle to engage with the camp aesthetic in compelling, humorous, and sometimes incongruous ways. As a sartorial manifestation of the camp sensibility, this thought-provoking publication contributes new theoretical and conceptual insights into the camp canon through texts and images. Stunning new photography by Johnny Dufort highlights works by such fashion designers as Virgil Abloh, Thom Browne, Jean-Charles de Castelbajac, John Galliano, Jean Paul Gaultier, Marc Jacobs, Karl Lagerfeld, Alessandro Michele, Franco Moschino, Miuccia Prada, Richard Quinn, Yves Saint Laurent, Elsa Schiaparelli, Jeremy Scott, Anna Sui, Gianni Versace, and Vivienne Westwood. (shrink)

This paper argues that Locke has a representative theory of sensitive knowledge. Perceivers are immediately aware of nothing but sensory ideas in the mind; yet perceivers think of real external substances that correspond to and cause those ideas, and they are warranted in believing that those substances exist (at that time). The theory poses two questions: what warrants the truth of such beliefs? What is it in virtue of which sensory ideas represent external objects and how do they make perceivers (...) think of those objects? Both the epistemic and semantic issues need to be addressed. This paper urges that Locke's basic account of warrant is roughly reliabilist. The causal origin of sensory ideas assures that, in general, sense based beliefs are true. Locke defines the limit of this warrant by the theoretical point that we cannot discuss skeptical doubt without assuming the truthfulness of our perceptual faculty. Turning to the semantic question, the paper argues that ideas are mental modifications or entities. They are not intrinsically representative (satisfiable), but rather represent only by virtue of their causal origin. They merely “track” the presence of substances and their qualities. Ideas nevertheless prompt perceivers to think of their causes. This is roughly because sensory ideas have a specific mental role, namely, to serve as marks for distinguishing substances and their respective qualities for purposes of action. The paper suggests that, for Locke, the challenge posed by the semantic veil of ideas is to explain this externally directed marking function within bounds of his anti‐innatism. But it concludes that his answers to the twin questions fit together reasonably well. (shrink)

This essay argues that aristotle's doctrine of nominal definition is his semantic theory for natural-Kind terms. It offers a new interpretation of that doctrine. On this interpretation nominal definitions are initial working theoretical accounts of natural kinds which serve as starting points for scientific inquiry. As such, Nominal definitions have existential import. They make an implicit reference to the most familiar actual instances of the kinds they define and they define the essences of those kinds by reference to those instances. (...) Nominal definitions are, Thus, Accounts of real essences as much as real definitions. They are initial incomplete accounts of such essences and it is as such that they explicate the meanings of (natural-Kind) terms. (shrink)

In Metaphysics IV.2 Aristotle assigns a very specific role to dialectic in philosophical and scientific inquiry. This role consists of the use of the special form of dialectic which he calls peirastic. This is not a new conception of, or a new role for, dialectic in philosophy and science, but one also assigned to it in the Topics and Sophistical Refutations. In the SE Aristotle lays down multiple overlapping requirements for the premises or bases for peirastic dialectical argument. These must (...) be things known by skilled practitioners of dialectic; things in fact in accord with the science or subject of the peirastic dialectical encounter in question; things known by non-experts as well as by experts in that subject, things known even by ordinary people in general; things believed by the answerer in the given peirastic encounter and things which are as noted and accredited as possible. We can see from Aristotle’s discussion and from his, and earlier, examples that all of these various requirements can be and are met by a single identifiable set of propositions, one whose use gives a special power to peirastic, one adequate to show the falsity of particular pretensions to knowledge on specific points, in science and philosophy. (shrink)

Over the last 50 years, the term professionalism has undergone a widespread expansion in its use and a semantic shift in its meaning. As a result, it is at risk of losing its descriptive and analytical value and becoming instead simply an empty evaluative label, a fate described by C. S. Lewis as ‘verbicide’. This article attempts to rescue professionalism from this fate by down-sizing its extension and reassigning some of its work to two other ethical domains, introduced as the (...) neologisms organizationalism and sur-moralism. Professionalism is defined as a morality based in system of obligations that are assumed by physicians over the course of their professional training and which primarily refer to two groups: patients and colleagues, including trainees. Organizationalism is also a morality, but the obligations are owed to the employing organization and on different grounds. A third ethical domain, here called sur-moralism, comprises actions that are not based in obligations. They are discretionary and potentially meritorious; they cannot be required by the profession or organization. This article presents a conceptual model of the three ethical domains and the shifting borders between them. One practical benefit of this typology is that physicians can more accurately understand the nature and sources of obligations that they are asked to accept, and when necessary prioritize them. Another is that physicians will be able to describe the potential tension between the three domains and understand how and why the borders between them can move. Both should help physicians to be more ethically oriented to their work settings. (shrink)

This interesting and challenging book addresses the apparent gap between the empiricist account of the origin of ideas and the theory of knowledge in the Essay concerning Human Understanding. Matthew Priselac makes an impressive argument that they are complementary parts of a coherent program. It consists of a naturalistic interpretation on which the Essay's main aim is to provide the kind of understanding of the mind, knowledge, and probability afforded by modern methods of natural scientific inquiry.On this view, the Essay (...) advances a hypothesis intended to explain the epistemic phenomena of everyday life, that is, what we take ourselves to know rather than hold as probable. It describes a process by which the... (shrink)

‘Shameful are the scars inflicted by the sin of fraternal strife! What has ourunconscionable generation shunned, what abomination left undone? Ourgodless soldiery has held nothing sacred. I pray that Fortune may, on a new anvil, give our blunted swords another shape, to use against Massagetae andArabs!‘.

Reading the moral philosophy of Iris Murdoch alongside film enables us to see Murdoch's notions of practical moral good in action. For Murdoch, moral philosophy can be seen as “a more systematic and reflective extension of what ordinary moral agents are continually doing”. Murdoch can help us further by her consideration of the value of a moral fable: does a morally important fable always imply universal rules? And how do we decide whether a fable is morally important? By bringing Murdoch (...) and Margaret together in an exploration of the moral decision making of the film's protagonist and our assessment of her choices, we can learn more about the idea of film as a morally important fable rather than a fable that is purely decorative. (shrink)

This article examines Ian McEwan's script for director Richard Eyre's film, The Ploughman's Lunch, the title of which alludes to a deceptive, post-World War II advertising campaign that promulgated a false narrative about British tradition. McEwan's script, and Eyre's film adaptation of it, offer a prescient exposé of Britain's culture of mendacity in the 1980s in ways that draw on rule-consequentialist ethics to maintain that lying on the personal, professional, and political level has a pernicious effect on society. McEwan's work (...) on the film also marks a crucial turning point in the author's career, one in which he first begins to explore complex ethical and moral conundrums that would figure prominently in his major fiction. (shrink)

Aristotle's word for science is epistêmê, which has at least a dual use in the Greek of his day and is standardly used, in one way, as a count noun, to mean “a science.” Thus, in this usage, one can say that geometry, or phusikê, or metaphysics is epistêmê, a science. Here the term epistêmê designates a special sort of systematic body of truth or fact that may or may not have yet been discovered, or fully discovered. In Plato's Protagoras, (...) Socrates uses the term epistêmê for knowledge of the particular right moral action to perform on some specific occasion and he is followed in this use of the term by Aristotle in Nicomachean Ethics VII.2. Aristotle claims that scientific principles are reached by induction. (shrink)

Les quatorze articles traduits dans ce volume constituent la premiere presentation d'ensemble d'une oeuvre importante dans le domaine de l'histoire de la philosophie ancienne. Ils s'etendent sur plus de vingt ans et portent tous sur ce que l'on pourrait appeler, au sens le plus large du terme, l' epistemologie aristotelicienne, en prenant epistemologie en son sens francais et non au sens que ce terme a dans le monde universitaire anglophone. Les textes ont ete ranges dans un ordre a la fois (...) systematique et pedagogique, et non dans un ordre chronologique, parce que, malgre d'inevitables changements de details, les positions adoptees par Robert Bolton sont restees fondamentalement les memes. Il est remarquable que, alors que Bolton semblait isole dans les annees 1970-1980, ses theses soient aujourd'hui au moins mieux comprises et meme, sans doute, plus largement partagees. Le merite le plus immediat de l'approche boltonienne d'Aristote, c'est de definir exactement la place de l'epistemologie aristotelicienne. Ce qui fournit un element important pour en cerner la nature. Ce faisant Bolton applique a l'Aristotelisme lui-meme l'un des traits qu'il cru deceler dans la methode d'Aristote: d'abord saisir un element de l'essence de la chose que l'on veut connaitre, comme premier pas vers la saisie de cette essence. (shrink)

Driven by the use cases of PubChemRDF and SCAIView, we have developed a first community-based clinical trial ontology (CTO) by following the OBO Foundry principles. CTO uses the Basic Formal Ontology (BFO) as the top level ontology and reuses many terms from existing ontologies. CTO has also defined many clinical trial-specific terms. The general CTO design pattern is based on the PICO framework together with two applications. First, the PubChemRDF use case demonstrates how a drug Gleevec is linked to multiple (...) clinical trials investigating Gleevec’s related chemical compounds. Second, the SCAIView text mining engine shows how the use of CTO terms in its search algorithm can identify publications referring to COVID-19-related clinical trials. Future opportunities and challenges are discussed. (shrink)

Macphail’s (1985) null hypothesis challenged researchers to demonstrate any differences in intelligence between vertebrate species. Rather than focus on differences, we asked whether rats would show the same unexpected, counterintuitive features of skill learning observed in humans: Factors that degrade performance during acquisition often enhance performance in a subsequent retention/autonomy phase. Providing post-trial “knowledge of results” (KR) on 30%-67% of trials instead of 100% degrades accuracy, yet increases retention in a subsequent phase without KR. We tested this feature by providing (...) three groups of rats with KR on every trial (100% KR), 67% KR, or 0% KR. We also provided operant feedback in every trial for completing the left-right lever-press skill (food for correct sequences, timeout for all others). In the autonomy phase, we assessed their ability to complete the skill independently—in the absence of differential cues and KR feedback. In agreement with human performance in the autonomy phase, 67% KR yielded higher skill accuracy than providing 100% KR. Also, providing 67% KR improved skill accuracy above that observed with operant feedback alone (0% KR). Rather than degrading performance during acquisition, the 67% KR condition yielded unexpected higher accuracy than the other conditions. Accuracy increased systematically across our extended acquisition phase, which provided each rat with over 3600 trials compared to 20-30 trials for human studies. Providing limited KR promoted skill learning in rats as it does in humans, consistent with the conjecture that both species share common learning processes. Introducing difficulties to rats during training improved their autonomy. (shrink)

Purpose. To examine the existential anthropology of G. Marcel and E. Minkowski, in order to demonstrate the necessity of distinguishing the universal-spiritual, as human in human being, apart from the individual-existential in him, and to reveal the hierarchical correlation of biosocial, existential and spiritual spheres in personality. Theoretical basis. Within existential philosophy the author differentiates two separate traditions and proceeds from the insufficiency of the distinction of existential sphere, proposed by phenomenological tradition, showing the necessity of its correlation with the (...) spiritual sphere as a sphere of humanity, proposed by non-phenomenological tradition of G. Marcel and E. Minkowski. Originality. The author presents the anthropological conception of G. Marcel and E. Minkowski, in which human personality is understood as unity of individual-existential and universal-spiritual, which requires a special trans-empirical field of culture, which contains senses, images and symbols of humanity. Also, the author presents the recent developments of existential thinkers in distinguishing existential and spiritual dimensions, both not reducible to the physical and social dimensions. Conclusions. In both existential traditions, the specifically human was founded as a trans-biological and trans-social phenomenon, which appears as indefinable and non-predetermined. But in first tradition, humanity is understood as an existence, as a unique individuality, "project", variant of humanity, equivalent to other variants, and universal is understood as a community of human condition in the world. While in the second tradition, the universal is understood as spiritual. Thus, horizontal level of our private existence, as the process of movement from birth to death, is supplemented by vertical of human, universal ideals and images. Humanity appears as a task, on the way to which human being transcends beyond the limits of his individual "self" to the "super-individual", through inclusion into spiritual community, into universal culture. (shrink)